Here is the proper way to avoid getting the dreaded “System.Security.SecurityException: Request for the permission of type ‘System.Web.AspNetHostingPermission, System, Version=2.0.0.0, Culture=neutral, PublicKeyToken=b77a5c561934e089′ failed.” error while attempting to get DotNetNuke 6.x installed onto Windows Server 2008 R2. download and extract the DNN installer.  In my case, I downloaded DotNetNuke_Community_06.01.03_Install and extracted it into a temporary directory. [...]